Reference of 69902-83-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 69902-83-6 name is 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
i). Preparation of 1-bromo-2-(bromomethyl)-3-(trifluoromethyl)benzene (i-4) To a solution of 1-bromo-2-methyl-3-(trifluoromethyl)benzene (i-4a) (2 g, 8.36 mmol) in CCl4 (20 mL) was added NBS (1.49 g, 8.36 mmol), dibenzoyl peroxide (20 mg, 0.08 mmol). The mixture was stirred under nitrogen at 100 C. for 16 h. The solvent was removed in vacuo, and the residue was partitioned between water (15 mL) and DCM (15 mL). The water layer was extracted with DCM (15 mL*3). The combined organic layers were dried over anhydrous Na2SO4 and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (PE/EtOAc=50/1) to afford the title compound (1.16 g, purity 80%, yield: 43%). LCMS (ESI) calc’d for C8H5Br2F3 [M+H]+: 317. found: 317.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, and friends who are interested can also refer to it.
Reference:
Patent; Barr, Kenneth J.; Bienstock, Corey E.; MacLean, John K.; Zhang, Hongjun; Beresis, Richard T.; Anthony, Neville J.; Lapointe, Blair T.; Sciammetta, Nunzio; US2015/210687; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary