Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 376646-62-7, name is (4-Bromo-2-methylphenyl)methanamine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of (4-Bromo-2-methylphenyl)methanamine
[0618j To a solution of 1-tert-Butyl-1H-pyrazole-4-carboxylic acid (1.4 g, 8.4 mmol) in DMF (20 mL) was added HATU (3.5 g, 9.2 mmol) and DIEA (4.4 mL, 25 mmol). The mixture was stirred at rt for 5 mm, followed by the addition of (4-bromo-2-methylphenyl)methanamine hydrochloride (2.0 g, 8.4 mmol). The reation was stirred at rt overnight, diluted with EtOAc, washed with water, and the organic phase was then dried (Na2SO4) and concentrated in vacuo to afford the crude product, which was purified by silica gel chromatography (EtOAc/heptane gradient) to give the title compound as a white powder (2.21 g, yield: 92percent). LCMS: RT 1.59 mm.; MH+ 350.0; ?H NMR (400 MHz, DMSO-d6) 5: 8.41 (t, J = 5.65 Hz, 1H), 8.29 (s, 1H), 7.89 (s, 1H), 7.28 – 7.44 (m, 2H), 7.16 (d, J = 8.03 Hz, 1H), 4.34 (d, J = 5.52 Hz, 2H), 2.30 (s, 3H), 1.52 (s, 9H).
According to the analysis of related databases, 376646-62-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; MA, Bin; CHAN, Timothy, Raymond; SUN, Lihong; ZHANG, Lei; KUMARAVEL, Gnanasambandam; LYSSIKATOS, Joseph, P.; KOCH, Kevin; MIAO, Hua; WO2015/89337; (2015); A1;,
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