Adding a certain compound to certain chemical reactions, such as: 1071449-08-5, name is 7-Bromo-2,3-dihydro-1H-inden-1-amine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1071449-08-5, Recommanded Product: 7-Bromo-2,3-dihydro-1H-inden-1-amine
To a solution of 7-bromo-2,3-dihydro-1 H-inden-1 -amine (ACS Med. Chem. Lett. 201 1 , 2, 565-570) (346 mg, 1 .63 mmol) and 3-(1 -(fe/ -butoxycarbonyl)piperidin-4-yl)-2-ethylpyridine 1 – oxide (250 mg, 0.816 mmol) and DIPEA (143 muIota_, 0.816 mmol) in CH2CI2 (5ml_), was added PyBrOP (761 mg, 1 .632 mmol). The reaction was stirred at room temperature for 76 h. The reaction was quenched with 1 N citric acid solution. The bi-layer was then separated. The aqueous layer was extracted twice with CH2CI2. The combined organic layers were washed with brine and dried over Na2S04, filtered, and then concentrated. The resulting residue was absorbed onto silica gel, and purified by silica gel flash column chromatography (0 to 60% EtOAc in CH2CI2) to afford the title compound. MS (ESI+) m/z 499.9 (M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromo-2,3-dihydro-1H-inden-1-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; ADAMS, Christopher Michael; BEVAN, Doug; CAPPARELLI, Michael Paul; EHARA, Takeru; FERRARA, Luciana; JI, Nan; KATO, Mitsunori; MAINOLFI, Nello; MEREDITH, Erik; MOGI, Muneto; POWERS, James J.; PRASANNA, Ganesh; (226 pag.)WO2016/1875; (2016); A1;,
Bromide – Wikipedia,
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