In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51776-71-7, name is 1-Bromo-4-(difluoromethyl)benzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: bromides-buliding-blocks
Example 38; 4-(4-Difluoromethyl-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide; A mixture of 4-hydroxy-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide (31a) (102 mg, 0.36 mmol), 1-bromo-4-difluoromethyl benzene (110 mg, 0.53 mmol), Cs2CO3 (174 mg, 0.53 mmol) and CuI (1 mg) in DMF (5 mL) was heated for 2 hr at 160 C. in the microwave. The mixture was filtered and the filtrate was purified by reverse phase chromatograph to give a white solid (18 mg, 12% yield). 1H NMR (400 MHz, CDCl3) delta 9.92 (d, J=2.02 Hz, 1H) 8.52 (s, 1H) 7.72 (dd, J=10.36, 1.77 Hz, 1H) 7.64 (d, J=8.34 Hz, 1H) 7.28 (s, 1H) 7.09 (t, J=7.96 Hz, 1H) 7.05 (s, 1H) 6.97 (s, 1H) 6.77 (d, J=2.02 Hz, 1H) 3.78 (s, 3H) 2.98 (s, 2H) 1.51 (s, 6H); LCMS for C22H21F2N3O3 m/z 414.00 (M+H)+.
The synthetic route of 51776-71-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pfizer Inc.; US2008/280875; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary