Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 875664-41-8, name is 3-Bromo-4,5-difluoroaniline, A new synthetic method of this compound is introduced below., Computed Properties of C6H4BrF2N
To a solution of 4-amino-A/-hydroxy-1 ,2,5-oxadiazole-3-carbimidoyl chloride (Int 7a) (250 mg, 1 .54 mmol) and 3-bromo-4,5-difluoroaniline (320 mg, 1 .54 mmol) in H20 and THF (12 mL, 1 :1 ) was added NaHC03 (194 mg, 2.31 mmol). The mixture was stirred at 65 C for 2 hours. Then the mixture was diluted with EtOAc (50 mL). The organic layer was washed with water (30 mL) and brine (30 mL), dried over Na2S04 and concentrated. The residue was purified by column chromatography on silica gel (PE: EtOAc = 5:1 ) to give the title compound as a white solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PHENEX DISCOVERY VERWALTUNGS-GMBH; STEENECK, Christoph; KINZEL, Olaf; ANDERHUB, Simon; HORNBERGER, Martin; KLEYMANN, Gerald; HOFFMANN, Thomas; (191 pag.)WO2018/83241; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary