Application of 1123172-38-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1123172-38-2 name is 1-Bromo-3-(tert-butyl)-5-fluorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
238 mg of bromo-3-tert-butyl-5-fluorobenzene (1.03 mmol; 1.03 eq.), 319 mg of methyl 1-[3-(4,4,5,5- tetramethyl- 1 ,3,2-dioxaborolan-2-yl)phenyl]azetidine-3-carboxylate (preparation 10; 1.00 mmol; 1 eq) and 4 mE of dioxane were added to a 12 mE Q-Tube reaction vessel. The medium was purged under vacuum and under argon. 41 mg of Pd(dppf)C12CH2C12 (0.05 mmol; 0.05 eq) and 415 mg of ground K2C03 (3.00 mmol; 3.00 eq.) were added, and then the reactor was sealed and heated at 114 C. for 20 h. The reaction medium was then filtered, rinsed with DCM and concentrated under reduced presure. The residue was purified by flash chromatography on silica using a cyclohexane/ 0% to 5% (cyclohexane/ethyl acetate) gradient. 237 mg of the title compound were obtained in the form of a yellow syrup.11071] Yld: 69%. ?H NMR (300 MHz, CHC13-d) oeppm 1.34 (s, 9H)3.53-3.66 (m, 1H) 3.75 (s, 3H) 4.05-4.11 (m, 4H) 6.48 (dd,J=8.0, 2.3 Hz, 1H) 6.6 (t, J=2.0 Hz, 1H) 6.94-6.99 (m, 1H)7.04 (m, 1H) 7.07 (m, 1H) 7.29 (t, J=7.8 Hz, 1H) 7.33 (t,J=1.7 Hz, 1H). LC-MS: mlz (M+H): 342.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-3-(tert-butyl)-5-fluorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; INVENTIVA; BOUBIA, Benaissa; MASSARDIER, Christine; GUILLIER, Fabrice; POUPARDIN, Olivia; TALLANDIER, Mireille; AMAUDRUT, Jerome; BONDOUX, Michel; FEENSTRA, Roelof Williem; VAN DONGEN, Maria Johana Petronella; (207 pag.)US2017/66717; (2017); A1;,
Bromide – Wikipedia,
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