Adding a certain compound to certain chemical reactions, such as: 959992-62-2, name is 6-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 959992-62-2, category: bromides-buliding-blocks
Compound 23.1 (320 mg, 1.49 mmol) And sodium hydrogen (179mg, 4.48mmol, 60%) The tetrahydrofuran (20 mL) solution was heated to reflux for 2 hours. Further, allyl chloroformate (540 mg, 4.48 mmol) was added to the above reaction system. The resulting reaction solution was further heated to reflux for 16 hours. Pour the reaction solution into the water. Extracted with ethyl acetate, The organic phase was separated and dried over anhydrous sodium sulfate. filter, concentrate, The residue was purified by prep-TLC ( petroleum ether / ethyl acetate = 1 / 1) to afford compound 23.4 (440 mg, yield: 67%) It is a colorless liquid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Dinuo Pharmaceutical Technology Co., Ltd.; Zhao Zhiming; Gao Daxin; Chen Shoujun; Wu Zhiheng; (105 pag.)CN108623615; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary