Synthetic Route of 927384-44-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 927384-44-9, name is 2-(4-Bromophenyl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine, This compound has unique chemical properties. The synthetic route is as follows.
A four-necked flask,4-hydroxy-phenyl boric acid 20.0g (0.15 mol),1,8-diaminonaphthalene protection p- bromophenyl boric acid 46.8g (0.15 mol),Take a potassium carbonate 31.1g (0.23 mol),Ethanol 140mL, was suspended in water 47mL.After the inside the flask was replaced by nitrogen gas,The addition of tetrakistriphenylphosphine palladium (0) 1.7g (1.5 mmol). After the mixture was heated with stirring for 7 hours at 80 ,It was diluted with toluene 300mL,It was separated treated with 5% hydrochloric acid 300mL.The solvent was evaporated,The compound represented by formula (I-60-1) by recrystallizing with acetone / hexane mixed solventIt was obtained 42.9g (0.13 mol).
The chemical industry reduces the impact on the environment during synthesis 2-(4-Bromophenyl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; DIC Corporation; Horiguchi, Masahiro; Hayashi, Masanao; Kusumoto, Tetsuo; (63 pag.)JP5962949; (2016); B2;,
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