Electric Literature of 35354-37-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35354-37-1 as follows.
Example 148 (+-)-trans-3,4-Dimethyl-N-(5-methylhexyl)-4-(3-n-propanesulfonylaminophenyl)piperidine To a solution of (+-)-trans-3,4-dimethyl-4-(3-n-propanesulfonylaminophenyl)piperidine (Preparation 40, 220 mg, 0.71 mmol) and 1-bromo-5-methylhexane (140 mg, 0.78 mmol) in N,N-dimethylformamide (7 ml) was added sodium hydrogen carbonate (120 mg, 1.42 mmol) and the resultant mixture was heated overnight at 100° C. The reaction mixture was poured onto water (50 ml) and extracted with diethyl ether (3*50 ml). The combined extracts were washed with brine (50 ml), dried (MgSO4), filtered and concentrated in vacuo to give the crude product which was purified by silica (5 g) chromatography using a gradient solvent system eluding initially with hexane:0.880 ammonia (100:1) then ethyl acetate:hexane:0.880 ammonia (50:50:1) to afford the title compound as a pale yellow oil (77 mg, 27percent). NMR (CDCl3, selected data for the free base): 0.75 (d, 3H), 0.9 (d, 6H), 1.0 (t, 3H), 1.2 (t, 2H), 1.25 (m, 2H), 1.3 (s, 3H), 1.4-1.65 (m, 5H), 1.8 (m, 2H), 2.0 (m, 1H), 2.5 (q, 2H), 2.8 (m, 1H), 3.05 (m, 2H), 7.0-7.3 (m, 4H). MS (APCI): M/Z [MH+] 409.3; C23H40N2O2S+H requires 409.3.
According to the analysis of related databases, 35354-37-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Armer, Richard Edward; Dutton, Christopher James; Gethin, David Morris; Gibson, Stephen Paul; Smith, Julian Duncan; Tommasini, Ivan; US2003/78282; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary