Some common heterocyclic compound, 51776-71-7, name is 1-Bromo-4-(difluoromethyl)benzene, molecular formula is C7H5BrF2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H5BrF2
General procedure: Protocol A: The 0.020 M, THF solution obtainedfrom a 0.30 mmol scale preparation of R?CF2 reagent was combined with an electrophile (i.e., substrate) (0.30 mmol) dissolved in 3.0 mE THF at -80 C. The reaction mixture was then allowed to warm to room temperature and allowed to stand for 10 minutes. The solution was poured into saturated NH4C1 in H20 (50 mE) and the organics extracted into DCM (3×50 mE). The organic extract was dried with Mg504, filtered, concentrated onto 3 grams of silica gel, and purified by flash chromatography as specified.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51776-71-7, its application will become more common.
Reference:
Patent; REGENTS OF THE UNIVERSITY OF MICHIGAN; Szymczak, Nathaniel; Geri, Jacob; US2020/2362; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary