Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21865-50-9, name is 6-Bromo-2,3,4,9-tetrahydro-1H-carbazole, A new synthetic method of this compound is introduced below., Safety of 6-Bromo-2,3,4,9-tetrahydro-1H-carbazole
While purging with nitrogen gas in a 1L round bottom flask at room temperature,6-bromo-1,2,3,4-tetrahydrocarbazole (100 g, 400 mmol),Iodinebenzene (122 g, 600 mmol),Copper iodide (3.80 g, 20.0 mmol),Potassium phosphate (178g, 840mmol),1,2-cyclohexane diamine (91.3 g, 800 mmol),1,4-dioxane (500 mL) was added and refluxed for 12 hours. After TLC confirms the end of the reaction,After cooling the reaction solution to room temperature,Methylene chloride and water were added to separate the layers. The aqueous layer was removed and the organic layer was concentrated under reduced pressure,Purification by silica gel column chromatography gave <1-a>(86.5 g, 265 mmol). (Yield 66.3%)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SFC Ltd.; Shin Bong-gi; Kim Si-in; (80 pag.)KR102004386; (2019); B1;,
Bromide – Wikipedia,
bromide – Wiktionary