Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41825-73-4, name is 2-Bromo-4,6-dimethylaniline, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Bromo-4,6-dimethylaniline
To a solution of the N-Boc-piperidine-4-carboxylic acid (4.00 g, 17.5 mmol) in CH2C12 (80 mL) stirred under N2 at room temperature was added oxalyl chloride (1.50 mL, 17.2 mmol) followed by DMF (68 uL, 0.88 mmol). The reaction was stirred for 1 h and Et3N (5.5 mL, 40 mmol) was added followed by the addition of 2-bromo-4, 6-dimethyl aniline (2.60 mL, 20.8 mmol) and 4- (dimethylamino) pyridine (210 mg, 1.72 mmol). After stirring for 18 h at room temperature, the reaction mixture was diluted with CHUCK (100 mL) and washed sequentially with HC1 (1N aq. , 3 x 100 mL) and NaHCO3 (sat. aq. , 100 mL). The organic layer was dried with MgS04, filtered, and concentrated. Purification by silica gel chromatography (15% ethyl acetate in hexanes) gave 4- (2-bromo-4, 6-dimethyl-phenylcarbamoyl)-piperidine-1-carboxylic acid tert- butyl ester (2.75 g, 6.94 mmol, 40% yield) as a white powder.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2005/63745; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary