41825-73-4, name is 2-Bromo-4,6-dimethylaniline, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C8H10BrN
In 100mL Schlenk flask 2-bromo-4,6-dimethyl aniline (manufactured by Kanto Chemical Co., Inc.) (4.97g, 24.9mmol) and di-tert-butyl dicarbonate (manufactured by Kanto Chemical Co., Inc.) (13.6g, 62.1mmol) They were weighed, and dissolved by adding dehydrated toluene (manufactured by Kanto Chemical Co., Inc.) (35 mL). Introducing a reaction vessel in an oil bath preset at 90 C., and reacted for 33 hours. After completion of the reaction, the solvent was removed by silica column chromatography (hexane: ethyl acetate = 20: 1) as a white solid (2-bromo-4,6-dimethylphenyl) – carbamic acid tert-butyl ester was isolated ( 5.10g, 17.0mmol, 68%).
The synthetic route of 41825-73-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tokyo Institute of Technology; JapanPolychemCo., Ltd.; Osakada, Kotaro; Takeuchi, Daisuke; Takano, Shigenaga; Uchino, Hideshi; Kobayashi, Minoru; (93 pag.)JP2015/117237; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary