Adding a certain compound to certain chemical reactions, such as: 1379295-90-5, name is 2-Bromo-4,5,6,7-tetrahydrobenzo[d]thiazol-6-amine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1379295-90-5, HPLC of Formula: C7H9BrN2S
Step (ii): Preparation of N-(2-Bromo-4^,6,7-tetrahydro-benzothiazol-6-yl)-propionamide A solution of 2-Bromo-4,5,6,7-tetrahydro-benzothiazol-6-ylamine (0.36 grams, 1.5 mmol, obtained in above step) and triethylamine (0.43 mL, mmol) in dichloromethane (15 mL) was cooled to 0 C. Propionylchloride (0.17 mL, 1.8 mmol) in dichloromethane (2 mL) were added and stirred the reaction mass for 30 minutes. After completion of reaction, the mass was poured onto ice cold water and the product was extracted with ethyl acetate (3 x 15 mL). Thecombined organics were washed with water followed by brine, dried over anhydrous sodium sulphate and the organic volatiles were evaporated under vacuum. The residue was purified by flash chromatography (methanol / chloroform, 2 / 98) to obtain the title compound (0.4 grams). – NMR (delta ppm): 0.81 – 0.85 (1H, m), 1.14 – 1.18 (3H, m), 1.20 – 1.28 (2H, m), 1.90 – 1.96 (1H, m), 2.02 – 2.05 (1H, m), 2.18 – 2.23 (2H, m), 2.57 – 2.63 (1H, m), 2.86 – 2.91 (1 H, m), 3.10 – 3.15 (lH, m);Mass (m/z): 289.2 (M+H)+, 291.2 (M+3H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-4,5,6,7-tetrahydrobenzo[d]thiazol-6-amine, and friends who are interested can also refer to it.
Reference:
Patent; SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; SHINDE, Anil, Karbhari; KAMBHAMPATI, Ramasastri; NAMALA, Rambabu; DWARAMPUDI, Adi, Reddy; KOTA, Laxman; GAMPA, Murlimohan; KODRU, Padmavathi; TIRIVEEDHI, Taraka, Naga, Vinaykumar; KANDIKERE, Vishwottam, Nagaraj; MUDDANA, Nageshwara, Rao; SARALAYA, Ramanatha, Shrikantha; JAYARAJAN, Pradeep; SHANMUGANATHAN, Dhanalakshmi; AHMAD, Ishtiyaque; JASTI, Venkateswarlu; WO2012/29070; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary