Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 766-96-1, name is 1-Bromo-4-ethynylbenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-4-ethynylbenzene
To a 50 mL test tube was added the crude product from above (0.306 g, 1.69 mmol), 1-bromo-4-iodobenzene(0.478 g, 1.69 mmol), Pd(PPh3)4 (0.057 g, 0.05 mmol), and CuI (0.019 g, 0.10 mmol). To a separate test tubewas added tetrahydrofuran (20 mL), and triethylamine (5 mL). Each tube was sealed with a rubber septumand purged with a continuous stream of argon (5 min). The contents of the liquids tube were transferred tothe solids tube via cannula under argon. The resulting mixture was stirred at 50C under argon for 24 h. Theresulting suspension was extracted between dichloromethane and 5% NH4OH (aq). The organic layer wasseparated and dried over MgSO4. After filtration to remove the drying agent, the solvent was removed viarotary evaporation to give a brown-orange powder. 1H NMR spectrum matched that previously described.8This crude 4,4?-dibromotolane product was used directly in the next step without further purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Christensen, Joseph A.; Fletcher, James T.; Tetrahedron Letters; vol. 55; 33; (2014); p. 4612 – 4615;,
Bromide – Wikipedia,
bromide – Wiktionary