These common heterocyclic compound, 1159977-65-7, name is 6-Bromoimidazo[1,2-b]pyridazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1159977-65-7
To a solution of 6-bromoimidazo[1,2-b]pyridazine (1.98 g, 10.0 mmol) in methanol (50 mL) at -10 C. was added N-iodosuccinimide (2.47 g, 11.0 mmol) in portions. The mixture was stirred at -10 C. for 30 minutes and then allowed to warm up to rt. The reaction was continued to stir at rt for 18 hours, and then concentrated in vacuo. The residue was dissolved in 100 mL of DCM and washed with 50 mL of aqueous Na2CO3 solution. The organic phase was concentrated in vacuo to give the title compound as a light yellow solid (2.0 g, 61%). MS (ESI, pos. ion) m/z: 323.9 [M+H]+; 1H NMR (400 MHz, CDCl3): delta 7.83 (s, 1H), 7.78 (d, J=9.4 Hz, 1H), 7.21 (d, J=9.4 Hz, 1H).
The synthetic route of 6-Bromoimidazo[1,2-b]pyridazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Calitor Sciences, LLC; Xi, Ning; US2014/134133; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary