Synthetic Route of 5153-40-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5153-40-2 name is 1-Bromo-2,3,4,5,6-pentamethylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The synthesis of salicylaldimine 13 was accomplished in five steps (FIG. 21). Negishi cross-coupling of 1 and pentamethylbromobenzene[Ref 54] afforded biphenyl species 9. Subsequent steps are similar to the synthesis of ligands 7-s and 7-a. Bromination, followed by lithium-halogen exchange and DMF treatment installed the formyl moiety to give 11. Deprotection of the ether group and condensation with 2,6-diisopropyl aniline provided 13 in 14% overall yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2,3,4,5,6-pentamethylbenzene, and friends who are interested can also refer to it.
Reference:
Patent; RADLAUER, Madalyn; WIENSCH, Joshua D.; BUCKLEY, Aya K.; AGAPIE, Theodor; US2013/66029; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary