Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1159977-65-7, name is 6-Bromoimidazo[1,2-b]pyridazine, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H4BrN3
To a solution of intermediate 26B (100 mg, 0.246 mmol) in 1,4-dioxane (3 mL) was added BisPin (94 mg, 0.3 70 mmol) and potassium acetate (72.6 mg, 0.73 9 mmol). The solution was purged with argon for 2 mm. and PdC12(dppf)-CH2C12 adduct (10.06mg, 0.0 12 mmol) was added. The reaction mixture was heated at 90 C for 3 h and cooled to RT. 6-Bromoimidazo[1,2-bjpyridazine (48.8 mg, 0.246 mmol), aqueous 3M K3P04 solution (0.370 mL, 0.739 mmol) and PdC12(dppf)-CH2C12 adduct (10.06 mg, 0.012 mmol) were added. The reaction mixture was heated at 90 C for 16 h, cooled to RT and concentrated in vacuo. The crude product was purified by silica gelchromatography (12 g RediSep column, eluting with a gradient of 40-100 % EtOAc in petroleum ether). Fractions containing the desired product were combined and evaporated under reduced pressure to afford intermediate 26B (30 mg, 27.4 % yield). MS (ES): m/z = 444.5 [M+Hj HPLC Ret. Time 1.25 mm. (HPLC Methods B).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1159977-65-7.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; LIU, Peiying; TEBBEN, Andrew J.; VELAPARTHI, Upender; RAHAMAN, Hasibur; TONUKUNURU, Gopikishan; WARRIER, Jayakumar Sankara; (264 pag.)WO2018/17633; (2018); A1;,
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