Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69902-83-6, name is 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Formula: C8H6BrF3
Step 1 : A mixture of 1-bromo-2-methyl-3-(trifluoromethyl)benzene (100 mu, 0.64 mmol), 4,4,5,5-tetramethyl-2-(tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 ,3,2- dioxaborolane (327 mg, 1.29 mmol), PdCI2dppf DCM (26 mg, 0.030 mmol) and potassium acetate (158 mg, 1.61 mmol) in 1 ,4-dioxane (5 mL) was heated in a sealed tube at 80C overnight. The mixture was run through a plug of silica (EtOAc), concentrated and purified by preparative HPLC to give 4,4,5,5- tetramethyl-2-[2-methyl-3-(trifluoromethyl)phenyl]-1 ,3,2-dioxaborolane.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; HOMAN, Evert; HELLEDAY, Thomas; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; FISKESUND, Roland Julius Yu; (359 pag.)WO2015/187089; (2015); A1;,
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