These common heterocyclic compound, 32863-30-2, name is 4-(Bromomethyl)benzo[c][1,2,5]oxadiazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H5BrN2O
Compound 9-2 (44.5 mg, 0.1 mmol) and 4-(bromomethyl)benzo[c][1,2,5]oxadiazole 14-1 (32 mg, 0.15 mmol) were dissolved in dry DMF Add cesium carbonate (65.2mg, 0.2mmol) and stir at room temperature for about two hours. The reaction is complete. the reaction solution was extracted with water and ethyl acetate. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. PE: EA = 5: 1 to give 20 mg of compound 14-2.
The synthetic route of 4-(Bromomethyl)benzo[c][1,2,5]oxadiazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhang Ao; Geng Meiyu; Song Zilan; Ai Jing; Gu Wangting; Liu Bo; Ding Jian; (28 pag.)CN110240587; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary