Related Products of 105309-59-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105309-59-9, name is Tetrakis(4-bromophenyl)methane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
The H4MTBC bridging ligand was prepared in two steps as shown in FIG. 11. First, the intermediate tetramethyl 4?,4??,4???,4????-methanetetrayltetrakis([1,1?-biphenyl]-4-carboxylate) (Me4MTBC) (CAS: 1208241-39-7) was synthesized using a modified procedure from the literature. Tetrakis(4-bromophenyl)methane (723 mg, 1.14 mmol, 1 equiv.), Pd(PPh3)4 (132 mg, 0.114 mmol, 0.1 equiv.), 4-(methoxycarbonyl)phenylboronic acid (1.23 g, 6.82 mmol, 6 equiv.) and CsF (3.11 g, 20.46 mmol, 18 equiv.) were charged in a 120 mL high-pressure reaction tube and pumped into an N2 glove box. To the reaction tube was added 60 mL of degassed dimethoxyethane, and the tube was capped and stirred at 85 C. for 3 days. Progress of the reaction was monitored by thin layer chromatography (TLC) (1% EtOAc/CHCl3). After cooling to room temperature, the reaction mixture was transferred to a round-bottom flask and evaporated with a rotavap. The resulting solid was dissolved with CHCl3 and filtered through celite to remove CsF and Pd nanoparticles. The filtrate was evaporated with a rotavap, then purified by flash column chromatography on silica gel using 1% EtOAc/Hexane as eluent to give white solid as pure product (572 mg, 59% yield). 1H NMR (500 MHz, CDCl3): delta 8.10 (d, 3JH=8.3 Hz, 8H), 7.68 (d, 3JHH=8.3 Hz, 8H), 7.59 (d, 3JHH=8.4 Hz, 8H), 7.44 (d, 3JHH=8.5 Hz, 8H), 3.94 (s, 12H).
The synthetic route of Tetrakis(4-bromophenyl)methane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; The University of Chicago; Lin, Wenbin; Manna, Kuntal; Ji, Pengfei; (83 pag.)US2018/361370; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary