Application of 40422-70-6, These common heterocyclic compound, 40422-70-6, name is 1-Bromo-3-(2-bromoethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To prepare Fen-Br Meta, N-phenyl-N-piperidin-4-yl-propionannide (Norfentanyl, 0.93 g, 4.0 mmol) and 3-bromophenethyl bromide (1.58 g, 6.0 mmol) were dissolved in 15 mL DMF, followed by addition of N,iV-diisopropylethylamine (0.78 g, 6.0 mmol). The reaction was kept stirring at 60 C for 24 hours. The reaction mixture was cooled to room temperature before ethyl ether (100 mL) was added, and the organics were washed with 1 N NaOH (30 mL x 3), water (30 mL x 3) and brine (30 mL x 3). The organics were then dried over MgS04 and concentrated under vacuum. The organics were redissolved in ethyl ether, and pure Fen-Br was precipitated as HCl salt by addition of HCl in ethanol solution. Fen-Br Meta (93%). NMR (500 MHz, CDCb): delta 7.55-7.35 (m, 5H), 7.18 (dd, J = 8.5, 8.5 Hz, 2H), 7.09 (d, J = 8.5 Hz, 2H), 4.80 (tt, J = 12.0, 4.0 Hz, 1H), 3.62 (d, / = 12.0 Hz, 2H), 3.12 (m, 2H), 2.89 (td, J = 12.0, 1.5 Hz, 2H), 2.2-1.8 (m, 6H), 1.42 (m, 2 H), 1.01 (t, / = 7.5 Hz, 3H).
Statistics shows that 1-Bromo-3-(2-bromoethyl)benzene is playing an increasingly important role. we look forward to future research findings about 40422-70-6.
Reference:
Patent; ALLEGHENY-SINGER RESEARCH INSTITUTE; AVERICK, Saadyah; BADR, Ahmed; LI, Shaohua; LEJEUNE, Keith; (83 pag.)WO2017/41095; (2017); A1;,
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