Application of 707-34-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 707-34-6, name is 1,3,5-Tribromoadamantane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE I Synthesis of 1,3,5-Triethynyladamantane Vinyl bromide (60 mL) was added, dropwise, over 1.5 h to a solution of 1,3,5-tribromoadamantane (43 g, 115 mmol) and aluminum chloride (10 g) in CH2 Cl2 (100 mL) at a rate such that the internal temperature did not exceed -20 C. The progress of reaction, as indicated by the disappearance of 1,3,5-tribromoadamantane, was monitored by GLC and 1 H NMR. The reaction mixture was stirred at -20 C. for 1.5 hours, diluted with dichloromethane and poured slowly over crushed ice and concentrated hydrochloric acid (40 mL). The organic layer was separated and the aqueous layer was extracted with dichloromethane. The combined organic layers were washed with water, dried (MgSO4) and filtered and solvent was evaporated under reduced pressure to give 80 g of crude 1,3,5-tris(2,2-dibromoethyl)adamantane. The crude material was dissolved in DMSO (350 mL) and potassium t-butoxide (80 g, 714 mmol) was added portion-wise over a period of 20 minutes. The mixture was stirred at ambient temperature for 48 h, diluted with dichloromethane and poured over crushed ice/water/concentrated hydrochloric acid (5 mL). The organic layer was separated and the aqueous layer was extracted with dichloromethane. The combined organic layers were washed with water and brine, dired (MgSO4), filtered and stripped of solvent under reduced pressure to give an oil. This oil was distilled under reduced pressure (120-130 C./0.5 mm) to give 14,6 g (61%) of 1,3,5-triethynyladamantane. An analytical sample was recrystallized from pentane: mp. 84-86 C; IR 3350 and 2150 cm-1; 1 H NMR delta 2.13 (s, 3 H, C CH) and 1,96 (s, 6 H) and 1.79 (m, 7 H); Anal. Calcd for C16 H16; C, 92.26; H, 7.74. Found: C, 92.10; H, 7.79.
The synthetic route of 1,3,5-Tribromoadamantane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Baum; Kurt; Archibald; Thomas G.; Malik; Aslam A.; US5017734; (1991); A;,
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