Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51776-71-7, name is 1-Bromo-4-(difluoromethyl)benzene, A new synthetic method of this compound is introduced below., Product Details of 51776-71-7
Step 2: To a 250mL round-bottom flask was added 150mL toluene, compound 12b (19g, 0.09mol, l .Oq), Benzyl mercaptan (12.5g, O. lmol, l . leq), DIPEA (23.7g, 0.18mol, 2.0eq), [l, -bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane (3.7g, 0.005mol, 0.05eq) and 4,5- bis(diphenylphosphino)-9,9-dimethylxanthene (5.3g, 0.009mol, O. leq). The reaction was heated to reflux for 15h. The reaction mixture was concentrated in vacuum and purified by column chromatography on silica gel eluted to afford the title compound 12c (15g). Yield: 65%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; LIANG, Congxin; (62 pag.)WO2018/5713; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary