Related Products of 1435-54-7, These common heterocyclic compound, 1435-54-7, name is 1,3-Dibromo-2-fluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-isopropylphenol 0.1 mol,Dissolved in 100 mL of anhydrous tetrahydrofuran,Stirring, accurately weighing 0.4 moles of sodium hydride in batches added to the reaction flask,Do not be too fast to prevent too much bubble generated, plus the solution after the yellow,Then add 1,3-dibromo-2-fluorobenzene 0.11mol, also added in batches, room temperature reaction overnight. The resulting reaction product was filtered,Remove the solid material, the filtrate spin dry, add methylene chloride dissolved,Column column with petroleum ether: ethyl acetate = 1: 5 (volume ratio)To give 1,3-dibromo-2- (2-isopropylphenoxy) benzene (Intermediate A-1) (0.05 mol, y = 50%).
The synthetic route of 1435-54-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jilin Optical and Electronic Materials Co., Ltd.; Cui, Dunzhu; Gao, Chunji; Wang, Hui; Ma, Xiaoyu; Li, Ming; Li, Wenju; (54 pag.)CN106187963; (2016); A;,
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