Synthetic Route of 113899-55-1, A common heterocyclic compound, 113899-55-1, name is 1-(2-Bromophenyl)ethylamine, molecular formula is C8H10BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1) Di-t-butyl dicarbonate (1.26 ml) was added to a solution of 1-(2-bromophenyl)ethanamine (1.0 g) obtained by the method described in the literature (Tetrahedron Letters, 2007, vol. 48, p.4589) in chloroform (10 ml), and the resulting mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (chloroform:methanol = 50:1) to obtain a protected compound (1.52 g).
The synthetic route of 113899-55-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; Meiji Seika Kaisha, Ltd.; EP2287173; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary