Synthetic Route of 179737-33-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 179737-33-8 as follows.
In an Ar atmosphere, 20.00 g (73.56 mmol) of 2,3-dibromo-1,4-difluorobenzene, 12.30 g (1.1 equiv, 80.9 mmol) of 2-methoxyphenylboronic acid, 80.92 g (3 equiv, 220.7 mmol) of K2CO3, 4.25 g (0.05 equiv, 3.7 mmol) of Pd(PPh3)4, and 515 mL of a mixed solution of toluene/EtOH/H2O (4/2/1) were sequentially added to a 1,000-mL three-neck flask, and heated and stirred at a temperature of 80 C. for 5 hours. After cooling to room temperature, the reaction solution was extracted therefrom by using toluene. A water layer was removed therefrom, and an organic layer was cleaned by using saturated saline and dried by using MgSO4. MgSO4 was filtered and separated and the organic layer was concentrated. A crude product obtained therefrom was purified by silica gel column chromatography (mixed solvent of hexane and toluene was used in a development layer) to obtain Intermediate IM-1 (16.94 g, yield of 77%). (0394) Intermediate IM-1 was identified by observing the mass number m/z=299 as the molecular ion peak through FAB-MS.
According to the analysis of related databases, 179737-33-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Samsung Display Co., Ltd.; Uno, Takuya; (153 pag.)US2019/389877; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary