Reference of 121086-19-9,Some common heterocyclic compound, 121086-19-9, name is 4-Bromo-N-isopropylaniline, molecular formula is C9H12BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Compound 18a-d (2.55mmol), 8a (2.55mmol), toluene (15mL), ethanol (12mL), NaOH (1.56M, 7mL), Pd(OAc)2 (0.05mmol), PPh3 (0.204mmol), was mixed under N2. The mixture was warmed to reflux for 5h. The mixture was diluted with EtOAc (20mL), washed with water and brine, and dried over MgSO4. The solvent was removed and the residue was separated by silica gel column chromatography using CHCl3/MeOH as an eluent to give 19a-d.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-N-isopropylaniline, its application will become more common.
Reference:
Article; Liu, Jie; Liu, Qin; Yang, Xue; Xu, Shengtao; Zhang, Hengyuan; Bai, Renren; Yao, Hequan; Jiang, Jieyun; Shen, Mingqin; Wu, Xiaoming; Xu, Jinyi; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7742 – 7751;,
Bromide – Wikipedia,
bromide – Wiktionary