Application of 90562-10-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 90562-10-0, name is 1-Bromo-4-(3-bromopropyl)benzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H10Br2

Example 139. l-[3-(4~Bromo-phenyl)-propyn-pyrrolidine C80); [0324] To a solution of compound 79 described in Example 138 (3.5 g, 13 mmol) in dioxane (40 mL) was added pyrrolidine (2.1 mL, 25 mmol) followed by cesium carbonate (8.2 g, 25 mmol). The mixture was stirred at room temperature for 15 h and poured into water. The mixture was extracted with ethyl acetate and the organic layer separated, EPO washed with brine, dried over Na2SO4 and filtered. The filtrate was concentrated and the residue purified by flash chromatography on silica gel (10% MeOH/DCM to 25% MeOH and 2% TEA/DCM) to afford the title compound (1.8 g, 53%) as a pale orange oil.[0325] 1H NMR (500 MHz, DMSO-d6): delta 1.60-1.65 (m, 6H), 2.35 (t, J= 7.3 Hz, 2H), 2.35-2.43 (m, 4H), 2.57 (t, J= 7.7 Hz, 2H), 7.16 (d, J= 8.3 Hz, 2H), 7.44 (d, J= 8.4 Hz, 2H).

The synthetic route of 90562-10-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TARGEGEN, INC.; WO2006/101977; (2006); A2;,
Bromide – Wikipedia,
bromide – Wiktionary