Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 112-89-0, Name is 1-Bromooctadecane, SMILES is CCCCCCCCCCCCCCCCCCBr, belongs to bromides-buliding-blocks compound. In a document, author is Szymanska, Martyna, introduce the new discover, Name: 1-Bromooctadecane.
Thiophene-benzothiazole dyad ligand and its Ag(I) complex – Synthesis, characterization, interactions with DNA and BSA
The aim of the reported research is to evaluate the significance and potential role of the thiophene moiety in potential DNA and BSA targeting drugs. For this purpose a Thiophene-BenzoThiazole tandem molecule (TBT) and its mononuclear silver(I) complex [Ag(TBT)(2)](+) was synthesized. The research was carried out using spectroscopic techniques such as circular dichroism (CD), UV-Vis and fluorescence. Based on the presented results the intercalating type of binding to DNA by complex [Ag(TBT)(2)](+) and ligand TBT was observed. The binding is spontaneous in both cases and the Kb values of both compounds are similar (K-b = 6. 40 x 10(5) and K-b = 5.83 x 10(5) for ligand TBT and complex [Ag(TBT)(2)](+), respectively). Yet, this type of interaction was confirmed in ethidium bromide competitive binding experiments and a special emphasis should be put on the higher Ksv value for complex [Ag(TBT)(2)](+) (5.1 x 10(4)) than ligand TBT (3.4 x 10(4)), since it may be the result of the bisintercalation of the complex. It has found confirmation in the increase of the melting temperature (T-m) of DNA treated with complex [Ag(TBT)(2)](+) of similar to 5 degrees C, while in analogues experiment with ligand TBT T-m was only similar to 1 degrees C higher. The bisintercalation of the complex is possible since two TBT ligands are bound to the metallic center with planar thiophene moieties placed on the same site. Furthermore, the complex [Ag(TBT)(2)](+) caused more significant changes in the secondary structures of the model protein BSA than the ligand TBT as determined by CD (reduction of alpha-helix content by 95 times in presence of the complex vs. stabilization of BSA structure with TBT). It needs to be emphasized, that both compounds bind to BSA via static quenching mechanism, however [Ag(TBT)(2)](+) has a higher affinity to it than the ligand itself (as evidenced by the extent of hyperchromism). Both compounds interact in hydrophobic site of the protein, however [Ag(TBT)(2)](+) exhibits higher Stem-Volmer constant K-sv 1.66 x 10(5) in comparison to TBT K-sv = 1.24 x 10(5). The Scatchard equation allowed one to estimate the compound:BSA binding ratio as 1:1 and 2:3 for ligand and complex, respectively. Moreover, the binding constant Kb is higher for complex (K-b = 4.05 x 10(7)) than ligand (K-b = 3.70 x 10(5)). It confirms that, indeed, both compounds may be distributed by albumins in the body, however the {(BSA)(3) – [Ag(TBT)(2)](2)(+)} adduct is more stable. The synchronous fluorescence spectra indicated that both compounds bind better in Trp than Tyr residues, therefore they may serve as potential molecular targets. (C) 2020 Elsevier B.V. All rights reserved.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 112-89-0 is helpful to your research. Name: 1-Bromooctadecane.