Reference of 615-36-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 615-36-1, Name is 2-Bromoaniline, SMILES is NC1=CC=CC=C1Br, belongs to bromides-buliding-blocks compound. In a article, author is Zhu, Qi, introduce new discover of the category.
Effects of genistein on lipopolysaccharide-induced injury of mouse alveolar epithelial cells and its mechanism
Alveolar and bronchial epithelial cells have critical functions in acute respiratory distress syndrome progress. Genistein could protect the lungs from acute lung injury, however, whether genistein protects the alveolar epithelial cells from LPS-induced injury was less studied. Spectrophotometric method 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and enzyme-linked immunosorbent assay (ELISA) were performed to detect cell viability and levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and IL-6. Flow cytometry and western blot assay were performed to detect cells apoptosis and protein levels. In LPS-induced model of mouse lung epithelial (MLE)-12 cells, PBEF (proinflammatory cytokine) expression, and cell apoptosis were increased and cell viability was decreased, whereas NF-kappa B was activated and expression levels of TNF-alpha, IL-1 beta, and IL-6 were increased. However, genistein partly reversed the effect of LPS, and it plays a protective role in lung injury by reducing expression of PBEF, inhibiting the activation of NF-kappa B and alleviating inflammatory response of cells.
Reference of 615-36-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 615-36-1 is helpful to your research.