In an article, author is Roy, Subhasish, once mentioned the application of 29823-18-5, Name is Ethyl 7-bromoheptanoate, molecular formula is C9H17BrO2, molecular weight is 237.1341, MDL number is MFCD00037103, category is bromides-buliding-blocks. Now introduce a scientific discovery about this category, Name: Ethyl 7-bromoheptanoate.
Accelerating Effect of DMAP on CuI Catalyzed Buchwald-Hartwig C-N Coupling: Mechanistic Insight to the Reaction Pathway
An efficient methodology has been developed for C-N cross-coupling reaction between aryl halide and amine using a catalytic system comprised of CuI and N,N-dimethyl amino pyridine (DMAP). Coupling reactions were carried out in DMSO at 120 degrees C in presence of 5 mol% CuI, 20 mol% DMAP and 2.5 equivalent of KOH. Addition of DMAP was found to be beneficial in accelerating the rate of reaction significantly. Both aryl iodides and aryl bromides could be successfully coupled with different primary and secondary amines to furnish the desired cross-coupling product in high yield. A copper complex [Cu(DMAP)(4)I]I made by combining CuI and DMAP was found to produce superior result for the Buchwlad-Hartwig cross coupling reaction. The use of 2 mol% of the copper complex is sufficient to produce high yield of the product.
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