Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Safety of 5-Bromopentanoic acid2067-33-6, Name is 5-Bromopentanoic acid, SMILES is O=C(O)CCCCBr, belongs to bromides-buliding-blocks compound. In a article, author is Wang, Haiyang, introduce new discover of the category.
Potassium methoxide/disilane-mediated formylation of aryl iodides with DMF at room temperature
A formylation of aryl iodides at room temperature using a weaker base KOMe instead of BuLi was developed. The TMS-TMS disilane was discovered to play crucial roles in this formylation. It was found that the MeO- group of KOMe coordinated with two silyl groups of disilane to generate a hypercoordinate silane species. This hypercoordinate silane species reacted with aryl iodide to give an aryl carbanion, which underwent formylation with DMF to give an aryl aldehyde.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 2067-33-6. Safety of 5-Bromopentanoic acid.