In an article, author is Paul, Sudeep, once mentioned the application of 3958-60-9, Name is 1-(Bromomethyl)-2-nitrobenzene, molecular formula is C7H6BrNO2, molecular weight is 216.032, MDL number is MFCD00007184, category is bromides-buliding-blocks. Now introduce a scientific discovery about this category, Name: 1-(Bromomethyl)-2-nitrobenzene.
Copper-NHC Based Ullmann Catalysis in Water for Selective N-Arylation of 3-Aminophenols
Studies of environmentally benign catalytic methods are of great value in modern chemical synthesis, especially the chemo-selective construction of chemical bonds under green conditions. This work elucidates such preferential synthesis of C-N bond over C-O bond via selective N-arylation of 3-aminophenols using 1,3-bis-[2-hydroxyphenyl] imidazolium chloride (IHPHCl) and copper iodide as catalyst (1 mol %) in aqueous medium. Presence of chelating group (-OH) on IHPHCl enhances N-selectivity. Overall this is a simple and green method for selective N-arylation of 3-aminophenols with good substrate scope and yields (60-88 %). GC-MS, HRMS and other spectroscopic techniques were utilised in detailing the kinetics and mechanistic aspects.
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