Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , HPLC of Formula: C9H17BrO2, 29823-18-5, Name is Ethyl 7-bromoheptanoate, molecular formula is C9H17BrO2, belongs to bromides-buliding-blocks compound. In a document, author is Laksono, James P., introduce the new discover.
Polymorphism of TPH2 Gene rs120074175 Is Not Associated with Risk Factors of Schizophrenia
Context: Polymorphism on tryptophan hydroxylase 2 (TPH2) gene rs120074175 can cause the synthesis of neurotransmitter serotonin in the brain to reduce up to 80%. Reduced serotonin in the brain can cause dopamine release to occur continuously. Excess dopamine in the brain may cause positive symptom of schizophrenia. Aim: The aim of this study was to investigate the genotype distribution of TPH2 rs120074175 gene on patients with schizophrenia at Prof. Dr. Soerojo Magelang Psychiatric Hospital, Indonesia, and the relationship between the genetic polymorphism of the TPH2 rs120074175 gene against risk factors of schizophrenia. Settings and Design: This was a cross-sectional study. Materials and Methods: The method used was amplification refractory mutation systempolymerase chain reaction (ARMS-PCR). Whole blood from healthy subjects and patients with schizophrenia, Wizard genomic deoxyribonucleic acid (DNA) purification kit (Promega, Fitchburg, Wisconsin), PCR master mix (Promega), ARMS-PCR primers, ddH(2)O, agarose (Thermo Scientific, Seoul, South Korea), Tris, Acetic Acid, EDTA (TAE) 1X, ethidium bromide, loading dye 6x, and DNA ladder (Thermo Scientific) were the materials used. Statistical Analysis: Hardy-Weinberg equilibrium and chi-square (similar to 2) tests were used. Results: The results showed that both groups (healthy subjects and patients with schizophrenia) at the Prof. Dr. Soerojo Magelang Psychiatric Hospital have a wild-type GG genotype (100%) without anyone having a mutant A allele. Conclusion: TPH2 rs120074175 gene polymorphism was not associated with risk factors for schizophrenia.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 29823-18-5. HPLC of Formula: C9H17BrO2.