Related Products of 506-26-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 506-26-3, Name is (6Z,9Z,12Z)-Octadeca-6,9,12-trienoic acid, SMILES is CCCCC/C=CC/C=CC/C=CCCCCC(O)=O, belongs to bromides-buliding-blocks compound. In a article, author is Ferreira, Thalita C. S., introduce new discover of the category.
Effect of DODAB Nano-Sized Cationic Bilayer Fragments against Leishmania amazonensis
The dioctadecyldimethylammonium bromide (DODAB) is a double-chained cationic lipid with potent bactericide and fungistatic activities; however, its toxicity on protozoan parasites is still unknown. Here, we show the antileishmanial activity of DODAB nano-sized cationic bilayer fragments on stationary-phase promastigotes and amastigotes of Leishmania amazonensis, the causative agent of cutaneous leishmaniasis. Upon treatment with DODAB, we analyzed the parasite surface zeta-potential, parasite viability, cellular structural modifications, and intracellular proliferation. The DODAB cytotoxic effect was dose-dependent, with a median effective concentration (EC50) of 25 mu M for both life-cycle stages, comparable to the reported data for bacteria and fungi. The treatment with DODAB changed the membrane zeta-potential from negative to positive, compromised the parasite’s morphology, affected the cell size regulation, caused a loss of intracellular organelles, and probably dysregulated the plasma membrane permeability without membrane disruption. Moreover, the parasites that survived after treatment induced small parasitophorous vacuoles and failed to proliferate inside macrophages. In conclusion, DODAB displayed antileishmanial activity, and it remains to be elucidated how DODAB acts on the protozoan membrane. Understanding this mechanism can provide insights into the development of new parasite-control strategies.
Related Products of 506-26-3, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 506-26-3 is helpful to your research.