A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 941-37-7, Name is 1-Bromo-3,5-dimethyladamantane, molecular formula is C12H19Br. In an article, author is Hao, Junxing,once mentioned of 941-37-7, SDS of cas: 941-37-7.
Detection of Tumor Marker Using ZnO@Reduced Graphene Oxide Decorated with Alkaline Phosphatase-Labeled Magnetic Beads
The magnetic-bead-based electrochemical enzyme-linked immunoassay (MB-eElisa) represents an attractive approach to develop cost-effective systems that are suitable for sensing complex biological samples. Its sensitivity essentially depends on the transduction efficiency of enzyme catalytic reactions into electrochemical responses. Here, an ultrahigh signal-to-noise alkaline phosphatase (ALP)-based MB-eElisa system is developed with a renewable zinc oxide-reduced graphene oxide composite modified carbon paste electrode (ZnO@rGO/CPE). This biosensing system employs one antibody decorated MB (MB-Ab(1)) to capture a model tumor marker-carcinoembryonic antigen (CEA)-from samples, while other antibody coated gold nanoparticles-ALP bioconjugates (Ab(2)-AuNPs-ALP) convert 1-naphthyl phosphate (1-NPP) into electroactive 1-naphthol (1-NP). Benefitting from the unique electrochemical properties of a ZnO@rGO/CPE, including nearly zero background and significantly enhanced responses toward the hydrolyzed 1-NP in the presence of trace surfactants, the MB-eElisa system detects selectively CEA in a calibration range of 0.01-6.0 ng mL(-1) and with a detection limit of 4.0 pg mL(-1) (S/N = 3). Such a system was further applied to the detection of CEA in serum samples of cancer patients. The combination of MB-based ALP-linked immunoassay with a ZnO@rGO/CPE thus establishes a reusable and inexpensive electrochemical sensing platform for the rapid and sensitive detection of ultratrace biomarkers in complex biological samples.
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