Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24358-62-1, name is 1-(4-Bromophenyl)ethylamine, A new synthetic method of this compound is introduced below., Recommanded Product: 24358-62-1
[0207] To a mixture of l-(4-Bromophenyl)ethan-l -amine (1.0 g, 5.0 mmol, 1.0 equiv) and IPA (15 mL) in a microwave vial (20 mL) were added 4,6-dichloropyrimidine (0.89 g, 6.0 mmol, 1.2 equiv) and DIPEA (1.6 g, 12.0 mmol, 2.4 equiv). The vial was sealed and heated at 160 C in a microwave reactor for 1 h. The mixture was concentrated onto 5 g of Si02 and purified by silica gel chromatography (80 g column, 0-10% MeOH in DCM with 1% TEA) to provide 1.1 g (70%) of A-(l-(4-bromophenyl)ethyl)-6-chloropyrimidin-4-amine as a white solid. LRMS (ES) m/z 312.0 (M+H). 1 H-NMR (Chlorofom /, 400 MHz, ppm) d 8.29 (s, 1H), 7.46 (d, / = 8.4 Hz, 2H), 7.19 (d, / = 8.4 Hz, 2H), 6.19 (s, 1H), 4.79 (bs, 1H), 1.54 (d, 7 = 6.8 Hz, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CYTOKINETICS, INC.; MORGAN, Bradley P.; VANDERWAL, Mark; CHUANG, Chihyuan; (0 pag.)WO2020/5888; (2020); A1;,
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