In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 103-64-0, name is (2-Bromovinyl)benzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of (2-Bromovinyl)benzene
To a solution of N, N-dimethylformamide (DMF) in a volume ratio of 4: 1 with polyethylene glycol 200(PEG-200)) was added 100 mmol of the compound of the above formula (I), 40 mmol of the compound of the above formula (II), 11 mmol of catalyst bis (triphenylphosphine) cyclopentadienyl ruthenium chloride,100 mmol of oxidant bis (trifluoroacetic acid) iodobenzene (PhI (TFA) 2), 20 mmol of organic ligand L1 and 60 mmol of base, 5,7-triazabicyclo [4.4.0] dec-5-ene (TBD) Then the mixture was warmed to 70 C with stirring, and the reaction was stirred at that temperature for 12 hours;After completion of the reaction, the reaction system is naturally cooled to room temperature and the pH is adjusted to neutral, filtered and the filtrate is saturatedSalt water washing, and then extracted with ethyl acetate 2-3 times,The combined organic phases were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography,Was eluted with a mixture of chloroform and petroleum ether in a volume ratio of 1: 2 to give the compound of the above formula (III) in a yield of 77.3%.
The synthetic route of 103-64-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Huang, Cheng; No proclaimed inventor; (12 pag.)CN106278839; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary