Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6627-78-7, name is 1-Bromo-4-methylnaphthalene, A new synthetic method of this compound is introduced below., SDS of cas: 6627-78-7
To a stirred N-methyl-2-pyrrolidone (NMP, 70 mL) solution of 1-bromo-4-methylnaphthalene (13.3 g, 60.3 mmol) was added CuCN(27.0 g, 301 mmol) at room temperature. The solution was suddenly heated by an oil bath preheated to 200 C, then the solution was stirred at 200 C for 60 min. CHCl3 (500 mL) was added. The solution was washed with 10% NH3 aqueous solution (60 mL¡Á3). The combined organic layers were concentrated in vacuo to remove NMP. The brown solid was subjected to silica gel column chromatography (eluent:AcOEt) to give 1-cyano-4-methylnaphthalene (7.33 g, 43.8 mmol, 73%yield). Colorless solid; 1H NMR (300 MHz, CDCl3)delta 2.76 (s, 3 H), 7.36(d, J =8.0 Hz, 1 H), 7.64-7.73 (m, 2 H), 7.81 (d, J=8.0 Hz, 1 H), 8.08(dd, J = 8.3, 1.7 Hz, 1 H), 8.24 (dd, J = 8.3, 1.7 Hz, 1 H) ppm.
The synthetic route of 6627-78-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Maeda, Hajime; Enya, Kouhei; Negoro, Naoki; Mizuno, Kazuhiko; Journal of Photochemistry and Photobiology A: Chemistry; vol. 374; (2019); p. 173 – 184;,
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