Related Products of 38573-88-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 38573-88-5 as follows.
Isopropylmagnesiumchloride-LiCl complex (1,30 M in THF, 155.0 mL, 0.0715 mol) under nitrogen was cooled to 0-5 ¡ãC, and 2,3-difluorobromobenzene (13.8 g, 0.0715 mol, 1.50 equiv.) was added while T < 10 ¡ãC. After 1 h at 0-5 ¡ãC, a solution of 1 -morpholino-2-( 1 -(trityloxy)but-3-en-2-yloxy)ethanone 14 (21.8 g, 0.048 mol, 1.0 equiv.) in THF (2.0 vols) was added while T <10 ¡ãC. The reaction mixture was stirred for 2.5 hours and monitored for consumption of 1-morpholino-2-(l-(trityloxy)but-3-en-2-yloxy)ethanone (target >97percent). The reaction mixture was quenched by charging into cold sat. aq. NH4CI (110 mL) and water (33 mL) while T < 20 ¡ãC. 2-Methoxy-2-methylpropane (218 mL) was added and the layers were separated. The organics were washed with sat. aq. NH4CI (65 mL) and 18percent aq. NaCl (44 mL.). The organics were concentrated under vacuum T < 25 ¡ãC to a light yellow oil of ketone 15 (21.6 g).
According to the analysis of related databases, 38573-88-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ???????????????????????????; ? Buranko; Kimu ?; Chan ?; ?; Yoshizawa Kazuhiro; (94 pag.)JP2016/121177; (2016); A;,
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