Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4549-33-1, name is 1,9-Dibromononane, A new synthetic method of this compound is introduced below., Quality Control of 1,9-Dibromononane
General procedure: The synthesis of p-aminophenoxy alkanes was accomplished intwo steps, as shown in Fig. 1. In the first step various p-nitrophenoxyalkanes were synthesized according to the given procedure [28]. Finely powdered anhydrous potassium carbonate (7.86 g,57 mmol) was added to a solution of p-nitrophenol (8.0 g, 57 mmol) in DMF (50 mL) and toluene (30 mL). The reaction mixture was stirred at room temperature for 1 h under an inert atmosphere of nitrogen. Afterwards, dropwise addition of the corresponding dibromoalkane (28.5 mmol) was made over a period of 30 min andthe mixture was maintained at 120 C for 12 h. The conversion of reactants into the product was monitored by TLC (n-hexane: ethylacetate 1:4). After the complete consumption of reactants, the reaction mixture was cooled to room temperature and then precipitated in distilled water, filtered and recrystallized from ethanol. In the second step, 10% Pd/C (0.03 g) was added in solution of p-nitrophenoxy p-nitrophenoxyalkanes (4 mmol) in 90 mL of ethanol followed by the dropwise addition of hydrazinium monohydrate (3.8 mL) to the reaction mixture over a period of 1 h. The reaction mixture was refluxed for 3 h after which the catalyst was filtered off. The p-aminophenoxyalkanes (D3,D5,D9,D10 and D11) were obtained byprecipitation in distilled water, followed by drying and recrystallization in the smallest possible volume of ethanol [29].
The synthetic route of 4549-33-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Iqbal, Asma; Siddiqi, Humaira Masood; Akhter, Zareen; Qaiser Fatmi, Muhammad; Journal of Molecular Structure; vol. 1151; (2018); p. 135 – 141;,
Bromide – Wikipedia,
bromide – Wiktionary