In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1073-06-9, name is 1-Bromo-3-fluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C6H4BrF
To a solution of diisopropylamine (76 niL, 0.4 mol) in dry THF (664 mL) and n-hexane (220 mL) is added 2.5 M /?-BuLi (160 mL. 0.4 mol) dropwise at -780C during a period of 1 h. The mixture is stirred for 1 h at -780C. Then a solution of 1- bromo-3-fiuoro-benzene (69 g, 0.4 mol) in dry THF (300 mL) at -780C is added to the above mixture dropwise. After stirring for an additional 1 h at -780C, the mixture is added a solution of iodine (101 g, 0.4 mol) in dry THF (400 mL) dropwise at – 780C. The temperature is raised from -780C to rt during 2 h. After stirring for 18 h at rt, the mixture is concentrated in vacuo to give crude product (120 g) which is distilled under reduced pressure to afford l-bromo-3-fluoro-2-iodobenzene (110 g). 1H NMR (400MHz, DMSO): 7.24-7.19 (t, IH), 7.38-7.32 (m, IH), 7.55-7.53 (d, IH).
The synthetic route of 1073-06-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; VITAE PHARMACEUTICALS, INC.; WO2008/124575; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary