Synthetic Route of 103977-79-3, The chemical industry reduces the impact on the environment during synthesis 103977-79-3, name is 3-Bromo-2,4-difluoroaniline, I believe this compound will play a more active role in future production and life.
C. Ethyl 7-bromo-6,8-difluoro-4-hydroxyquinoline-3-carboxylate A stirred mixture of 26 g of 3-amino-2,6-difluorobromobenzene and 27 g of diethyl ethoxymethylenemalonate was heated at 150 C. for 1 hour. After cooling, 100 ml of Dowtherm “A” (commercially available high boiling inert solvent mixture of diphenylether and dibenzofuran) was added and the mixture was heated under nitrogen at 260 C. for 1.5 hour. The mixture was cooled to room temperature and 200 ml of hexanes was added. The resulting precipitate was collected by filtration, washed with hexanes and dried to give a cream solid, m.p. 285 C., yield 78% (32.32 g).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-2,4-difluoroaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Pfizer Inc.; US4623650; (1986); A;,
Bromide – Wikipedia,
bromide – Wiktionary