Application of 766-81-4, These common heterocyclic compound, 766-81-4, name is 3-Bromophenylacetylene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The catalyst [(IPr) AuCl] (3.1mg, 0.5mol%), 3- bromophenyl acetylene (1mmol), in methanol (1ml) and water (0.5ml) was added successively 25ml reactor.After the reaction mixture was reacted for 6 hours at 110 , cooled to room temperature.Rotary evaporation to remove the solvent, then purified by column chromatography (eluent: petroleum ether / ethyl acetate) to give pure title compound, yield: 93%
The synthetic route of 766-81-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing University of Science and Technology; WANG, NANA; MA, JUAN; LI, FENG; (10 pag.)CN106032348; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary