Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2924-09-6, name is 5-Bromo-2-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H5BrFN
A solution of sodium nitrate (0.49g, 0.007mM) in water [(1.] [5ML)] was added drop wise to a vigorously stirred heterogeneous solution of [5-BROMO-2FLUOROANILINE] (1.4g) in concentrated HC (aq) (3. [5ML)] over a 30 minutes period at 0C. Tin [(II)] chloride [DIHYDRATE] (4. 5g, 0.02mM) in concentrated [HC .] (aq) (3. 5ml) was added drop wise to the above solution over a period of 30 minutes. After the addition, the solution was allowed to stir at [0C] for one hour. The reaction solution was basified (pH>7) by slowly adding a solution of 50% aqueous NaOH to the reaction mixture. The water layer was washed with diethyl ether (3x). The organic layers were combined, dried [(MGS04),] and concentrated. The resultant solid was thoroughly washed with hexanes. The undissolved solid was captured on filter and further washed with hexanes to afford [0.] [81 G] (54% yield) of the desired product as an off- white solid. NMR [(CHC13)] [8] 5.45 (bs, 1H) ; 6.80-6. 86 (m, 2H); 7.25-7. 28 [(M,] 1H). [[0085]] See, McKittrick, B. et al. , J. Heterocyclic Chem. 27,2151 (1990), hereby incorporated by reference.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2924-09-6.
Reference:
Patent; WYETH; VIROPHARMA INCORPORATED; WO2003/99824; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary