Reference of 699-03-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A mixture of tetrafluoropyridazine 1, DIPEA, amine and THF (10 mL) was stirred for the required time under an atmosphere of nitrogen. The mixture was evaporated to dryness in vacuo, partitioned between ethyl acetate (20 mL) and water (20 mL), the phases were separated and the aqueous phase was extracted further by ethyl acetate (3 x 20 mL). The combined organic phases were dried (MgSO4) and evaporated in vacuo. Purification by column chromatography or HPLC on silica gel using cyclohexane and ethyl acetate as eluent gave the pure product.
The synthetic route of 1-(4-Bromophenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Pattison, Graham; Sandford, Graham; Wilson, Ian; Yufit, Dmitrii S.; Howard, Judith A.K.; Christopher, John A.; Miller, David D.; Tetrahedron; vol. 73; 5; (2017); p. 437 – 454;,
Bromide – Wikipedia,
bromide – Wiktionary