Electric Literature of 156682-52-9,Some common heterocyclic compound, 156682-52-9, name is 1,4-Dibromo-2,3-difluorobenzene, molecular formula is C6H2Br2F2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 4 (5 g, 18.1 mmol),1,4-dibromo-2,3-difluorobenzene (2.4 g, 9.0 mmol), Tetrakis (triphenylphosphine) palladium (0) (0.9 g, 0.9 mmol) Tetrahydrofuran (60 ml) and potassium carbonate 2M solution (20 ml) were added to a mixed solvent and refluxed for 24 hours.After completion of the reaction, the reaction solution was extracted with methylene chloride and methylene chloride / hexane mixed solvent was subjected to column chromatography with a developing solvent to obtain 4.3 g of intermediate 5.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dibromo-2,3-difluorobenzene, its application will become more common.
Reference:
Patent; LG Chem, Ltd.; Dankook University Cheonan Campus Industry-Academic Cooperation Foundation; Gu Gi-dong; Lee Gi-gon; Keum Su-jeong; Kim Gong-gyeom; Lee U-cheol; Lee Chil-won; Cha Jae-ryeong; Joo Yun-seok; (37 pag.)KR2019/109846; (2019); A;,
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