Electric Literature of 201138-91-2, A common heterocyclic compound, 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
10.43 g (32 mmol) of B-(9-phenyl-9H-carbazole-3-yl)boronic acid, 8.9 g (31.6 mmol) of 4,6-dibromodibenzofuran and 31 mL (63 mmol) of Na2CO3 (2 M solution) was then suspended in 120 mL of toluene and 120 mL ethanol. To this suspension, it was added 0.73 g (0.63 mmol) of Pd(PPh3)4 and heat the reaction mixture for 16 hours under reflux. After cooling, remove the organic phase, after filtration, washed three times with 200 mL through silica gel, and concentrated until dry. Recrystallization of the residue from toluene. The yield for the 73% of theory, 11.4 g
The synthetic route of 201138-91-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck patent GmbH; Hussain, Farham Amir; Martinopa, Irina; Yachi, Anya; Avelluley, Thomas; Kuriba, JonasFallentine; (111 pag.)KR2016/38006; (2016); A;,
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