Synthetic Route of 6274-57-3, These common heterocyclic compound, 6274-57-3, name is 1-(4-Bromophenyl)-N,N-dimethylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
nBuLi (2.5 M in hexanes, 2.15 mL, 5.37 mmol) was added dropwise to a solution of 1-(4- bromophenyl)-N,N-dimethylmethanamine (1.0 g, 4.67 mmol) in THF (10 mL) at -78 C and the reaction was stirred for 15 min. SO2 was bubbled through the solution for 5 min, then the reaction was warmed to RT. After 2 h, the reaction was concentrated to almost dryness then triturated with MTBE (40 mL) and the solid was filtered to afford the title compound (0.8 g, 71% yield) as a yellow solid.1H NMR (DMSO-d6) d 7.45 (d, J = 7.7 Hz, 2H), 7.30 (d, J = 7.6 Hz, 2H), 3.62 (s, 2H), 2.20 (s, 6H).
The synthetic route of 6274-57-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INFLAZOME LIMITED; MILLER, David; MACLEOD, Angus; THOM, Stephen; MCPHERSON, Christopher G.; ALANINE, Thomas; CARRILLO ARREGUI, Jokin; CIANA, Claire-Lise; SHANNON, Jonathan; VAN WILTENBURG, Jimmy; DEN HARTOG, Jacobus Antonius Joseph; (603 pag.)WO2019/211463; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary